The Buffalo secondary is very vulnerable, ranking among the league's worst units against the pass last season. Look for Brady to put up 300+ yards and 3-4 scores again this week.
Wes Welker/Deion Branch/Chad Ochocinco
The entire WR corps stands to benefit from the loss of TE Aaron Hernandez, but perhaps none moreso than Ochocinco. I expect him to break out with 5 catches, 60 yards and a score. Welker and Branch should each be in the 6 catch, 100 yard range while splitting 1-2 TDs. It's a "start all your Patriots" kind of week.
Benjarvus Green-Ellis/Danny Woodhead
The Patriots figure to put up plenty of points this week, so both RBs could easily post solid RB2 numbers. Look for BJGE to approach 80 yards and a score and Woodhead to post his best game of the season with 80 total yards and a 50/50 shot at finding the end zone.
The injury to Hernandez makes Gronk a sure-fire top 5 tight end. He should find the end zone on one of his 5 or 6 grabs. Pencil him in for at least 70 yards too.
Expect big things this week as the Pats pile up the points. 1-2 FGs and 5 XPs sounds reasonable.
Patriots Defense/Special Teams
The Bills' offense has been solid so far this year and should be able to put up at least 17-24 points. Don't expect a ton of sacks or turnovers either. This unit is a marginal play this week.